Genetic Diseases

TRINUCLEOTIDE REPEAT IN HUNTINGTONS DISEASE 1.Relationship between trinucleotide wear expansion and phe nonype variation in Huntington disease: Author : Russell J Snell , John C Macmillan , et al ; 2.Relationship between trinucleotide CAG twin space and clinical features of Huntington disease: Author: Susan E Andrew, capital of atomic number 25 Goldberg et al; R. Soundharya II yr genetic engineering SRM university Huntingtons disease is one of the trinucleotide tell disorder which are caused by length of fictionaliseed section of gene exceeding soil gene. All individuals have two copies of HTT gene that codes for protein huntingtin. HTT gene driven on the short arm of chromosome. HTT contains a sequence of 3 DNA bases : cytosine-adenine-guanine. Molecular analysis of a specific CAG repeat sequence in the Huntingtons disease gene in 440 Huntingtons disease patients and 360 normal controls reveals a range of 30-70 repeats in affected individual s and 9-34 in normals. Negative correlation was set between the number of repeats on the HD chromosome and advance of onset, regardless of the stop over up of the transmitting parent. HD is associated with the expansion of CAG trinucleotide repeat in a wise gene. Association were found between length and age of death.

sibling pair and parent-child analysis revealed that CAG repeats demonstrate only moderate instability. affected HD siblings had significant correlations for trinucleotide expansion which was not apparent for affected parent-child pair. biological science 202 1998 Fi This subject reflects the research and thoughts of a student at the conviction the paper was written for a race at Bryn Mawr College. l! ike other materials on Serendip, it is not mean to be classic but rather to help others nevertheless develop their feature explorations. Web links were active as of the time the paper was posted but are not updated. Contribute Thoughts | assay Serendip for Other Papers | Serendip Home rascal rst Web Reports On Serendip...If you requirement to get a full(a) essay, order it on our website: OrderEssay.net

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